HORDB

ID: hor002793
Uniprot ID: P01364
Protein name: Peptide 2
Gene name: NA
Organism: Aplysia californica (California sea hare)
Family: NA
Source: animal
Expression: Neurons R3-R14. A cluster of 12 giant neurons located on the right side of the abdominal ganglion.
Disease: NA
Comments: NA
Taxonomy: Aplysia (genus), Aplysiidae (family), Aplysioidea (superfamily), Aplysiida (order), Tectipleura, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: EAEEPSAFMTRL
Length: 12(52-63)
Propeptide: MQVLHLCLAVSIAVALLSQAAWSEEVFDDTDVGDELTNALESVLTDFKDKREAEEPSAFMTRLRRQVAQMHVWRAVNHDRNHGTGSGRHGRFLIRNRYRYGGGHLSDA
Signal peptide: MQVLHLCLAVSIAVALLSQAAWS
Modification: T1 Pyrrolidone carboxylic acid (Glu)
Glycosylation: NA
Mutagenesis: NA

Function: HRBP is a myoactive peptide that excites Aplysia heart and enhances gut motility in vitro.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002793_AF2.pdb

hor002793_ESM.pdb

Mass:	157691	Formula:	C59H93N15O21S
Absent amino acids:	CDGHIKNQVWY	Common amino acids:	E
pI:	3.98	Basic residues:	1
Polar residues:	2	Hydrophobic residues:	4
Hydrophobicity:	-50	Boman Index:	-2745
Half-Life:	1 hour	Half-Life Yeast:	30 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	49.17
Instability Index:	6603.33	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 2573895
Title: Aplysia californica neurons R3-R14: primary structure of the myoactive histidine-rich basic peptide and peptide I.
PubMed ID: 3549995
Title: Proteolytic Processing of the Aplysia Egg-Laying Hormone and R3-14 Neuropeptide Precursors